The issue with commercial biodiesel is it is a VERY effective solvent, and will slowly dissolve any rubber or synthetic rubber except Viton (turn it to mush). Which is pretty pricey. Its usually got a very high centane but its cloud points can easily be significantly higher temps than #2 diesel.
And yeah it will do that in significantly less than 100,000 miles....it will do it in a matter of months.
The home made stuff? Its frequently caustic and has unreacted methanol in it...how much depends on the skill of the person making it...but its always significantly higher than the commercial stuff. That's over and above its ability as a solvent.
Run a single tank of B100 or ever B50 through your car (if it can handle it being the key operating word) and there won't be any crud in your fuel system. Even B20 will clean the system out...it will just take a bit longer.
Never made it myself...but I came close to doing it. Then I found out my exclusive source used partially Hydrogenated Veggie oil (looked like heavy cream at room temp), Not desirable stuff to use for biodiesel used outside of the summer months. Had several close friends that made it for years.
But then...that was before I bought my Cruze. I have two Mercedes with OM617 Turbo diesels in them that loves biodiesel. My Truck...also a diesel...is another that's known to not be happy with that stuff. SO even some of the older IDI diesels can't stomach much of it. Not just Common rail.