I don't think the autoignition temperature of E85 is high enough. If it is, it won't be good on the fuel system.
I know of two trials using ethanol fuel in Diesel engines.
ADM (huge agri-business conglomerate) did it in 1992 with some Detroit Diesel engines they converted. The fuel used was 95% ethanol and 5% gasoline. Engines were modified with 23:1 compression (up from 18:1 in the standard 6V-92TA engines), injectors with larger holes, modified ECU, and glow plugs added for cold starts. Engine power was OK for the most part but injectors repeatedly needed to be replaced due to clogging with come coke/gum deposits.
In modern times, Scania (European truck manufacturer) offers an inline-5 engine for mass transit buses (but maybe they could and would offer it in semis if someone wanted to buy it?) that uses ED95 fuel. The fuel is 95% ethanol and then 5% of an ignition-improver (something with a high cetane number) that also acts as a lubricant and corrosion inhibitor in the fuel system. Maybe the 5% is a mixture of things to do all those jobs, but it's a blended fuel with 95% ethanol. For their engines, compression is all the way up to 28:1 and the exhaust is so clean that I don't think it needs a particulate filter.
There are also some dual-fuel engines that use natural gas. The Napa Valley Wine Train operates a vintage locomotive that uses compressed natural gas. I think the engine has an ECU programmed to always inject Diesel fuel at idle and as an ignition event, and the natural gas is fed into the engine intake through some sort of carburetor or fuel injection that mixes it all in and it's a gas drawn into the cylinders. The compression doesn't ignite the natural gas so they still need a pilot injection of Diesel fuel to ignite each combustion event as if it were like a spark plug. This also has some fall-back operation where they can run out of CNG fuel and switch back to using 100% Diesel in limited circumstances.