That's unusual. But I think there is an issue with the Bluetooth in the factory radios. If you don't "end" the Bluetooth session when turning off the car, then the radio doesn't go to sleep and can drain the battery. An example of this is shutting down the car while still talking on the phone, but there might be other examples.
I've noticed a pattern in other reports that suggest the car may not go to sleep if it's not locked.
Are you having problems with false "door open" alerts? If the car thinks a door is open, it probably won't go to sleep.
This is almost starting to remind me of the pass lock issue Malibu, Grand Am Cutlass had back in the early 2000s. The car thinks it is being stolen and will not fire/start but turns over. Does the car turn over just not start? In other words is it a "Crank no start" condition where it cranks but won't start. Do you have any lights on on the dash that would indicate a theft deterrent? If so, put the key in the ignition for @ 10 min in the on position and see if it starts then.