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P0301 indicates a misfire in cylinder #1 based on rotation speed of the crankshaft.

P2227 indicates that either the barometric pressure is out of range, or the reading isn't matching what the ECM thinks it should be.

The P0301 does suggest that cylinder #1 is the place to look. I'm not sure what to make of the P2227. It could cause rough running, but not the smoke or coolant smell.
 
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